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Antipsychotics are usually effective in relieving symptoms of psychosis in the short term.

The long-term use of antipsychotics is associated with side effects such as involuntary movement disorders, gynecomastia, and metabolic syndrome.

While these medications all have sedating and calming effects, their major effect is to reduce psychotic thinking and behavior.

In general, other drugs are safer and more effective if sedation is the entire aim.

Risperidone and aripiprazole were similarly activating and sedating, while paliperidone and brexipiprazole were found to be neither activating nor sedating.

HAMER, Pharm D, BCPP, Oregon State University College of Pharmacy, Corvallis, Oregon Am Fam Physician. Related Editorial The use of antipsychotic medications entails a difficult trade-off between the benefit of alleviating psychotic symptoms and the risk of troubling, sometimes life-shortening adverse effects.They are also associated with increased mortality in elderly people with dementia.First-generation antipsychotics, known as typical antipsychotics, were discovered in the 1950s.Second-generation antipsychotic agents, used for the treatment of schizophrenia and major depressive disorder (MDD), are associated with varying degrees of activating or sedating adverse effects (AEs), with some agents having both properties.These are the findings of a new quantitative study published in the Journal of Clinical Pharmacology.




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Economists, not typically an alarmist bunch, have called the situation a "demographic time bomb," which has led Japan to initiate a multi-pronged approach to reverse the trend.


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But it was probably the oddest couple I've ever seen! Posey and Reeves reportedly first met in 2004, when she approached him about a role in a silent action-adventure movie. His last long-term relationship ended in 2001, when girlfriend Jennifer Syme died in a car crash.


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But when it comes to breakups, there’s another phrase that rings true: hindsight is 20/20. I’ve been taking myself on dates—going to dinner or lunch by myself, or taking myself to the movies alone.


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Detroit-based rapper Eminem, for example, used misogyny in eleven of the 14 songs on his third studio album The Marshall Mathers LP (2000).